HGH Frag 176-191
C-terminal hGH fragment residues 176–191 — investigational; related ≠ AOD-9604.
Editorial review:Evidence snapshot
This drawer marks papers. It is not a plan, a dose, or a source. A paper is a bounded report. It is not a protocol. Grades name the object. They are not a safety rating.
Identity lock — closely related to AOD-9604 / AOD9401; do not merge grades. “HGH Frag 176-191” names a C-terminal fragment of human growth hormone (somatotropin) spanning residues 176–191. It is often confused with:
| Object | Typical literature identity | This drawer? |
|---|---|---|
| HGH Frag 176-191 | Residue span 176–191 as marketed/analytical name | Yes — grade only identity-matched papers |
| AOD9401 | Synthetic lipolytic domain of hGH residues 177–191 (Ng/Heffernan line) | Related, not identical — tag, do not treat as Frag proof |
| AOD-9604 | Tyr-hGH 177–191 (WAVE1 drawer; PubChem CID 71300630 quarantine related≠proof) | Different object — do not redo AOD; do not use AOD papers as Frag 176-191 efficacy |
PubChem lacks a clean, collision-free CID/CAS lock for “Frag 176-191” in this pass → identity fields To be confirmed; do not invent CAS. Object is an hGH fragment, not intact rhGH, not a GHRH analog, and not a GHRP. No approved indication. Off-label does not apply. There is no label to be off of. Rodent lipolysis on AOD9401 / AOD-9604 is not automatic Frag 176-191 human fat-loss proof.
Bottom line
PubMed papers that explicitly name Fragment 176-191 are sparse. The clearest identity-matched hit in this set is a 2022 nanoparticle / breast-cancer cell paper — not a human fat-loss RCT. The rich lipolysis/obesity preclinical set is largely AOD9401 (177–191 domain) and AOD-9604 (Tyr-177–191) — closely related C-terminal hGH lipolytic-domain chemistry, but not identity-matched to Frag 176-191 without sequence confirmation. Honest line: controlled human body-composition efficacy for Frag 176-191 is not established here. Point readers to the WAVE1 AOD-9604 drawer for that sibling object; do not copy AOD grades into this drawer.
Papers
Identity-matched — Frag 176-191 named
PMID 35783198 — Habibullah 2022
Tested: human growth hormone fragment 176-191 peptide co-formulated with doxorubicin-loaded chitosan nanoparticles against MCF-7 breast cancer cells (in-vitro cytotoxicity enhancement object).
Does not show: a human fat-loss or obesity trial, or equivalence to AOD-9604 / intact hGH therapy.
Related objects — NOT Frag 176-191 proof (identity trap)
PMID 11116208 — Ng 2000
Tested: synthetic lipolytic domain AOD9401 of hGH containing residues 177–191 in Zucker fatty rats (lipase/acetyl-CoA carboxylase, adipocyte size, weight-gain).
Does not show: identity match to Frag 176-191; do not badge as Frag efficacy. Related C-terminal domain chemistry only.
PMID 10950816 — Heffernan 2000
Tested: oral AOD-9401 synthetic hGH fragment on lipid metabolism in obese mice and human adipose tissue ex vivo.
Does not show: Frag 176-191 human RCT; AOD9401 ≠ automatic Frag 176-191.
PMID 11146367 — Ng 2000
Tested: metabolic studies of synthetic lipolytic domain AOD9604 of human growth hormone.
Does not show: Frag 176-191 proof. AOD-9604 is a separate WAVE1 drawer — cite there, do not re-grade here as Frag.
PMID 11713213 — Heffernan 2001
Tested: chronic AOD9604 versus hGH on lipid metabolism in obese mice and β3-AR knockout mice.
Does not show: Frag 176-191 human efficacy.
PMID 9151258 — Strandberg 1997
Tested: NMR of a different C-terminal hGH fragment construct (I179–C182–[SS]–C189–P191 and related trisulfide) — structural chemistry.
Does not show: Frag 176-191 clinical fat-loss, or AOD-9604 equivalence.
Context, not a grade — axis / marketing narrative
PMID 42395176 — Dominikowski 2026
Tested: narrative review of performance-enhancing peptides on the GH–IGF-I axis; clinical evidence limited relative to self-administration culture.
Does not show: a controlled Frag 176-191 body-composition RCT.
What is not established
Approved fat-loss or metabolic indication for Frag 176-191. Controlled human weight-loss efficacy under a clean Frag 176-191 identity. Equivalence of Frag 176-191, AOD9401 (177–191), and AOD-9604 (Tyr-177–191). A locked PubChem CID/CAS for Frag 176-191 in this pack. Product identity for unlabeled “Frag” vials. Do not treat AOD papers as Frag proof or vice versa without sequence/identity match.
Selected sources
35783198 11116208 10950816 11146367 11713213 9151258 42395176
Reported experiences
Reported topics are not established benefits.Risks and unknowns
Compare experiences with care.
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