Investigational / not FDA-approved

PEG-MGF

PEGylated MGF E-domain lineage — scarce object-matched lit; ≠ naked MGF ≠ PEGylated IGF-I.

Editorial review:

What evidence says

Evidence snapshot

This drawer marks papers. It is not a plan, a dose, or a source. A paper is a bounded report. It is not a protocol. Grades name the object. They are not a safety rating.

Identity lock. PEG-MGF denotes a PEGylated form of mechano growth factor (MGF) — typically discussed as the IGF-1Ec E-domain peptide lineage — intended to alter pharmacokinetics versus naked MGF E-peptide. PEG-MGF ≠ native MGF / IGF-1Ec E-peptide; ≠ full-length IGF-1; ≠ PEGylated recombinant IGF-I drug candidates (different object — see Kletzl 2017 as contrast only). PubChem has no clean CID for “PEG-MGF” as a single defined conjugate in this pass. This drawer marks papers. It is not use advice.

Bottom line

PubMed hits that name PEGylated MGF specifically are scarce. Most indexed experimental work studies MGF E-peptide (non-PEGylated) in bone, tendon, and MSC models. Seized “cognitive / performance peptide” surveys may list MGF-class products as analytical findings without efficacy proof. Refuse performance / hypertrophy / muscle glow from this thin PEGylated-specific set. Do not pad with PEGylated IGF-I first-in-man data as if it were PEG-MGF.

Papers

MGF E-peptide (related ≠ PEG-MGF proof)

PMID 26622556 — Shang 2015

Tested: role of mechano-growth factor E peptide in osteosarcoma regulation (preclinical).

Does not show: PEGylated MGF human efficacy or safety.

PMID 27334712 — Zhang 2016

Tested: MGF E peptide in rat injured-tendon healing models.

Does not show: PEG-MGF identity or human tendon trials.

PMID 21057789 — Deng 2011

Tested: MGF E peptide on osteoblast proliferation and bone-defect healing in rabbits.

Does not show: PEGylated conjugate results.

PMID 24323763 — Cui 2014

Tested: MGF E peptide regulation of bone-marrow MSC migration/differentiation.

Does not show: PEG-MGF human data.

PMID 24768406 — Niu 2014

Tested: microencapsulation of MGF E peptide for sustained delivery (formulation science on E-peptide).

Does not show: a defined PEG-MGF clinical product.

Analytical / landscape (not efficacy)

PMID 31667971 — Vanhee 2020

Tested: occurrence of putative cognitive-enhancing research peptides in seized pharmaceutical preparations (analytical/control framing; MGF-class may appear in seizures).

Does not show: efficacy of PEG-MGF.

Different object — PEGylated IGF-I (do not grade as PEG-MGF)

PMID 28110155 — Kletzl 2017

Tested: first-in-man study of a novel PEGylated recombinant human IGF-I (not MGF E-peptide PEG conjugate).

Does not show: PEG-MGF results; included only as object-separation contrast.

What is not established

Any controlled human efficacy for PEG-MGF. Equivalence of PEG-MGF to naked MGF E-peptide or to PEGylated IGF-I. Muscle-growth claims. A locked PubChem CID for the PEGylated conjugate. This drawer does not provide use advice, schedules, or sourcing.

Selected sources

26622556 27334712 21057789 24323763 24768406 31667971 28110155

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